在整个生命周期中剖析人类皮层相似性网络
Xinyuan Liang1, Lianglong Sun1, Mingrui Xia1
1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Neuron
|July 24, 2025
概括
大脑网络从出生到成年期成熟,具有明显的区域变化和下降的形态-功能联系. 这项研究绘制了人类大脑发育的地图,并确定了大脑疾病中的偏差.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 网络科学 网络科学
背景情况:
- 人类大脑皮层显示区域相似性,但其寿命网络重建尚未完全理解.
- 研究整个生命周期的大脑网络的成熟对于理解典型和非典型发育至关重要.
研究的目的:
- 为了绘制人类一生中形态大脑网络的时空成熟的地图.
- 为了将网络生长模式与基因表达相关联,并确定大脑疾病中的偏差.
主要方法:
- 利用了来自0-80岁的33937名健康参与者的多式联络神经成像数据.
- 分析了全球网络架构,区域改造模式和形态功能合.
- 开发了基于形态测量网络的规范模型,以检测连接性-表型偏差.
主要成果:
- 全球大脑网络架构从出生到早期成年期成熟,增加模块化和小世界性.
- 观察到明显的区域重塑:感官皮层有所区分,准边皮层变得更相似,协会皮层保持枢纽稳定性.
- 形态功能合在青春期早期达到顶峰,表明功能成熟延长,并与特定的基因表达模式有关.
结论:
- 该研究提供了人类皮质网络在整个生命周期的重新配置的全面蓝图.
- 规范模型为量化个体间网络变异和识别大脑疾病中的偏差提供了一个基准.
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