相关实验视频

Updated: Sep 14, 2025

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Author Spotlight: Enhanced Murine AAA Model Using Elastase to Mimic Human Aneurysms

Published on: July 26, 2024

MFG-E8通过增强ERK MAPK/NOX4轴相关氧化应激加速腹腔大动脉动脉瘤的形成

Jie Xiao^1,2,3,4, Hai Hu^1,3,4, Minghui Zou^1,3,4

¹Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Cell proliferation

|July 24, 2025

概括

牛奶脂肪球-表皮生长因子8 (MFG-E8) 通过增加氧化应激,驱动腹腔大动脉动脉瘤 (AAA). 复星可以通过抑制MFG-E8和减少血管细胞亡来治疗AAA.

科学领域:

血管生物学血管生物学
蜂信号传输是如何进行的
氧化应激研究研究氧化应激研究

背景情况:

腹腔大动脉动脉瘤 (AAA) 是一种危及生命的疾病,其特征是大动脉的减弱和扩张.
氧化应激和血管光滑肌细胞 (VSMC) 亡是AAA病原发生的关键因素.
在AAA进展中MFG-E8的作用需要进一步阐明.

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MAPK Signaling Cascades

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...