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听力皮层子区域的变化及其对 tinnitus 患者声音治疗结果的预测

Ling Wang¹, Yu Zhang¹, Rui Zhao²

¹Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Brain research bulletin

|July 24, 2025

概括

听力皮层 (AC) 的结构和功能变化与耳有关. 在AC子区域和下圈之间的功能连接预测了声音治疗的成功.

科学领域:

神经成像是一种神经成像.
听觉神经科学听觉神经科学
医疗成像医学成像

背景情况:

耳是一种复杂的听力障碍.
了解耳的神经机制对于有效治疗至关重要.
确定治疗反应的生物标志物是一个重要的临床需求.

研究的目的:

调查 tinnitus 患者听力皮层 (AC) 亚区域的结构和功能变化.
为了确定神经成像指标,预测声音治疗的疗效.

主要方法:

在63名耳患者和38名健康对照中使用了高分辨率MRI (3D T1,DTI,rs-fMRI).
在交流子区域内比较灰色物质体积,分数异构性 (FA),低频波动幅度 (ALFF),分数ALFF (fALFF),区域同质性 (ReHo) 和功能连接性 (FC).
采用相关性和接收器运行特征 (ROC) 分析,将成像数据与临床结果联系起来,并预测治疗反应.

主要成果:

耳患者在AC亚区,特别是TE3.0.0.亚区,表现出改变的FA,ALFF,fALFF和ReHo.
有效的声音治疗组 (EG) 与无效组 (IG) 相比,在双边TE3.0和左下回 (ITG) 之间表现出更高的功能连接 (FC).
双边TE3.0和左侧ITG的组合FC值实现了0.811的曲线下的面积 (AUC) 来预测治疗结果.

结论:

在AC子区域发生显著的结构和功能变化,特别是TE3.0,在耳.
在AC重组的个体差异是声疗效的基础.
双边TE3.0和左侧ITG之间的联合FC作为 tinnitus 声疗法的可靠预测结果.

关键词:

听觉皮层重组的重组磁共振成像技术磁共振成像技术声疗法是一种声音疗法.亚区域子区域亚区域子区域声 (Tinnitus) 是一种听力障碍.

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