母亲吸烟会影响人类胎儿的X-无活化
Sanam Zeib Khan1, Linn Salto Mamsen2, Erik Ernst3
1Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3B, Copenhagen DK-2200, Denmark.
Reproductive toxicology (Elmsford, N.Y.)
|July 24, 2025
概括
怀孕期间母亲吸烟可能会延迟胎儿X染色体的不活化. 这一对于女性发育至关重要的过程,似乎涉及吸烟暴露的胎儿中更大的原始细胞池.
科学领域:
- 遗传学 遗传学 是一个
- 发展生物学 发展生物学
- 生殖健康 生殖健康
背景情况:
- X染色体无活化 (XI) 是雌性哺乳动物的一个关键过程,通常在植入前随机发生.
- 从随机XI的偏差,称为倾斜无活化,可能是由影响有限原始细胞池大小的因素引起的.
- 母亲吸烟与抑制生长和减少胎儿淋巴细胞数量有关,可能会影响XI.
研究的目的:
- 为了研究孕妇在怀孕期间吸烟对胎儿X染色体失活模式的影响.
- 要确定吸烟是否影响原始细胞池大小,从而影响X-无活化的随机性.
- 分析吸烟和非吸烟母亲的胎儿组织中的X-无活化比率 (XI比率).
主要方法:
- 在胎儿组织中使用雄激素受体基因 (AR) CAG重复的X无活化比率 (XI比率) 的分析.
- 孕妇吸烟 (n=8) 和非吸烟 (n=10) 的胎儿之间的XI比率的比较.
- 从XI比率的方差计算原始池的大小.
主要成果:
- 在吸烟母亲的胎儿中观察到的XI比率的更紧密分布,表明潜在的更大的原始细胞池.
- 在非吸烟母亲的胎儿中发现了更倾斜的X-无活化 (>=80%) 和更高的平均XI比率.
- 研究结果表明,母亲吸烟可能导致胎儿X-无活化的延迟.
结论:
- 孕妇在怀孕期间吸烟似乎会影响胎儿X染色体不活化.
- 在暴露于吸烟的胎儿中,较大的原始细胞池可能导致延迟的X-无活化.
- 这项研究提供了证据支持吸烟影响早期发育过程,影响X失活时间的假设.
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