奥米克朗变种在医疗机构显著增加病毒载量排放:对医疗保健工作人员的影响
F Rossi1, K-P Pelletier1, M Veillette2
1Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval (CRIUCPQ-UL), Québec City, Québec, Canada; Département de Biochimie, de Microbiologie et de Bio-informatique, Laval University, Québec City, Québec, Canada.
医疗保健工作者在病房中因空气中传播的病毒颗粒而面临显著的SARS-CoV-2暴露. 空气传播病毒载荷受患者的症状,如吐和房间特征的影响,需要加强感染控制措施.
科学领域:
- 环境科学 环境科学
- 传染病流行病学 传染病流行病学
- 职业健康 职业健康 职业健康
背景情况:
- SARS-CoV-2 的 Omicron 变种通过水滴和气溶传播.
- 卫生保健机构的通风不良和高患者密度构成空气传播病毒传播的风险.
研究的目的:
- 评估现实世界卫生保健工作者接触COVID-19患者的情况.
- 使用连续24小时空气采样测量空气中SARS-CoV-2水平.
主要方法:
- 在10个医院病房进行空气采样,其中38名SARS-CoV-2阳性患者.
- 用RT-qPCR检测空气样本中的Omicron变种.
- 病毒排放率计算并与患者症状和房间因素相关联.
主要成果:
- 在89%的患者和76.7%的房间的空气样本中检测到SARS-CoV-2.
- 每名患者的平均病毒排放率为1.45 × 10^5个基因组/小时.
- 排显著增加了排放率;房间的特点解释了差异的一半.
结论:
- 医疗保健工作者经历了大量接触空气传播的SARS-CoV-2.
- 需要加强策略来管理病房和减少向医护人员传播的风险.
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