成年人阻塞性肺功能及其早期生活关联的遗传风险
Casper-Emil T Pedersen1, Anders Eliasen2, Kasper Fischer-Rasmussen3
1COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
对阻塞性肺功能的遗传倾向在出生时就显而易见,增加了儿童喘和感染的风险. 早期的干预可以改善成年人的肺部健康.
科学领域:
- 肺部医学 肺部医学
- 遗传学 是一个遗传学.
- 儿科 儿科 儿科
背景情况:
- 慢性阻塞性肺病 (COPD) 可能起源于生命早期,由于产前和产后风险因素,包括遗传倾向.
- 了解对阻塞性肺功能遗传易感性的生命早期表现对于及时干预至关重要.
研究的目的:
- 调查成年人阻塞性肺功能遗传倾向是否可在出生和童年期间检测到.
- 评估这种遗传倾向与肺功能,支气管反应能力和从出生到青春期的喘相关症状的关联.
主要方法:
- 开发了成人阻塞性肺功能 (FEV1/FVC) 的多基因风险评分 (PRS).
- 在COPSAC出生队列中,PRS与新生儿和儿童肺功能,支气管反应能力,喘和呼吸道感染有关.
- 在大型iPSYCH队列中,PRS还与为喘息,喘和感染住院的病例有关.
主要成果:
- FEV1/FVC PRS与新生儿肺功能受损 (FEV0.5/FVC) 显著相关,持续到青春期.
- 较高的PRS与严重喘息/喘发作和需要住院治疗的下呼吸道感染的风险增加相关,可在出生后几个月内检测到.
- 在COPSAC2000队列中,没有证据表明喘恶化在18岁时调解了PRS-肺功能关联.
结论:
- 对阻塞性肺功能的遗传倾向在出生后不久就显而易见.
- 这种倾向增加了生命早期对严重喘息,喘和下呼吸道感染的易感性.
- 产前和幼儿时期是改善成人肺部健康的干预措施的关键窗口.
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