插入和提取空洞的金字塔微针的动力学:实验和数值建模
Rahul Nadda1, Diganta Bhusan Das1, Tahir Emre Yalcin2
1Chemical Engineering Department, Loughborough University, Loughborough LE11 3TU, UK.
International journal of pharmaceutics
|July 24, 2025
概括
优化空洞的金字塔微针 (HMNs) 用于药物输送需要了解插入和提取力. 这项研究开发了一种经过验证的模型,显示较小的HMN尺寸和更宽的间距可以减少所需的力,同时保持完整性.
科学领域:
- 生物材料工程 生物材料工程
- 机械工程 机械工程
- 皮肤病学 皮肤病学
背景情况:
- 微针 (MN) 技术提供了最少的侵入性药物输送.
- 了解MN插入和提取过程中的机械力对于设备设计和患者舒适性至关重要.
- 空洞微针 (HMN) 具有独特的制造和机械挑战.
研究的目的:
- 为了研究空洞的金字塔微针 (HMN) 的插入和提取动态.
- 开发和验证HMN机制的数学模型,考虑HMN和皮肤的非线性材料特性.
- 评估HMN关键设计参数对插入和提取力的影响.
主要方法:
- 制造空洞的金字塔形微针 (HMN).
- 实验室实验测量插入和提取力.
- 开发一个结合非线性材料行为的计算模型.
- 在多层皮肤模型中进行HMN插入/提取的数值模拟.
主要成果:
- 在实验和计算结果之间发现了良好的一致性,验证了数学模型.
- 该模型用于模拟各种条件下的HMN插入和提取.
- 确定了影响插入/提取力的关键参数,包括HMN尺寸和间距.
结论:
- 长度小于600微米的HMN,底径小于300微米,尖端直径小于30微米,针间距大于800微米,小于9个HMN显著减少插入和提取力.
- 这些优化的参数保持了金字塔式HMN的机械和结构完整性.
- 经过验证的模型为设计高效的基于HMN的药物输送系统提供了有价值的工具.
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