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强迫性应对行为,主要由信号追踪者发展,由慢性阿托莫克赛丁加剧
Chloe S Chernoff1, Aude Belin-Rauscent1, Mickaël Puaud1
1University of Cambridge, Cambridge, UK, Department of Psychology.
强迫性行为,如高垂体症,受到noradrenergic机制的影响. 信号跟踪预测超大的发展,而阿托莫克赛丁会加剧它,并改变关键大脑区域的基因表达.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 失去对应对策略的控制可以导致冲动性/强迫性谱系障碍 (ICSDs).
- 鼠在应对行为上表现出个体差异,有些人在时间表诱导的多症 (SIP) 条件下出现过度饮酒 (过度饮酒).
- 诺拉基因机制,特别是通过阿托莫克赛丁,可以防止易受感染的老鼠发展超症.
研究的目的:
- 为了调查noradrenergic机制是否影响已确立的超.
- 为了确定信号跟踪是否预测过度吸血症的发展.
- 探索原子素和信号跟踪在强迫性应对行为中的作用.
主要方法:
- 两项纵向研究使用雄性Sprague-Dawley大鼠进行.
- 鼠被暴露在一个时间表诱导的多症 (SIP) 程序中.
- 使用qPCR分析了像背上条纹体和核这样的大脑区域中的基因表达 (c-fos,zif268).
主要成果:
- 信号跟踪与更快的SIP获取和强迫性饮酒的发展相关.
- 慢性阿托莫西因加剧了高腹,并在背上条纹体中增加了c-fos和zif268mRNA水平.
- 阿托莫克赛丁改变了核贝和桃体-状系统中的基因表达.
结论:
- 诺拉基控制在强迫性应对行为的发展和表达之间有所不同.
- 信号跟踪是发展超症的一个脆弱性特征.
- 强迫性应对涉及不同的条形状过程,受到noradrenergic机制的影响.
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