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Updated: Sep 14, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
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Published on: February 14, 2025

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构成性IL-7信号传递促进了固体瘤微环境中的CAR-NK细胞存活,但损害了瘤控制

Matthew Dysthe1, Ishwar Navin2, Dayenne van Leeuwen2

  • 1Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA.

Journal for immunotherapy of cancer
|July 24, 2025
PubMed
概括

构成性活跃的互白素-7受体 (C7R) 增强了瘤中化学抗原受体 (CAR) -NK细胞存活率,但长期损害了抗瘤功能. 持续的IL-7信号传递可能会对固体瘤中CAR-NK细胞的疗效产生不利影响.

关键词:
收养细胞疗法 - ACT化学抗原受体 - - CAR细胞因子细胞因子自然杀手 - - NK - - 是一种自然杀手.瘤微环境 - - 瘤微环境

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