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Updated: Aug 6, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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酵母模型系统表明,异质表达的突变ATP9通过导致ATP枯竭对细胞生长产生负面影响

Takeshi Ito1, Kenta Terai2,3, Hidetaka Kosako2

  • 1Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.

Biological & pharmaceutical bulletin
|July 24, 2025
PubMed
概括

通过突变的线粒体ATP合成酶子单元向ATP枯竭提供了一种针对害虫,病原体和癌症的新策略. 引入单个突变的Atp9亚单元会使酶失活,从而耗尽细胞ATP.

关键词:
这是ATP合成酶.没有激活的失活.一个突变的突变者.下单元c是c子单元.酵母模型系统是酵母模型系统.

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相关概念视频

ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased ATP...