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早期后深度大脑刺激在帕金森病的精神病不良事件:一个叙事审查

Arteen Ahmed¹, Matthew Butler², Camille Wratten³

¹Psychological Medicine, King's College Hospital NHS Foundation Trust, London, UK arteen.1.ahmed@kcl.ac.uk.

Journal of neurology, neurosurgery, and psychiatry

|July 24, 2025

概括

在帕金森病 (PD) 深度大脑刺激 (DBS) 后,早期精神问题很常见. 这些事件通常通过调整DBS参数或药物来改善,突出显示需要监测情绪健康.

科学领域:

神经学神经学
神经外科神经外科
精神病学是一个精神病学.

背景情况:

深度大脑刺激 (DBS) 治疗帕金森病 (PD) 的运动症状.
精神病学因素显著影响DBS手术后的生活质量.
亚thalamic核 (STN) 和内部球 (GPi) 是主要的DBS目标.

研究的目的:

在PD患者的DBS后审查早期 (<2周) 的精神病不良事件 (AEs).
评估这些AEs的患病率和对先前存在的精神症状的影响.
探索DBS向和参数对精神病治疗结果的影响.

主要方法:

一个叙事审查研究的早期精神病的结果后,PD的DBS.
在多个数据库中进行了全面的文献搜索.
从148项相关研究中,包括了55项专注于早期精神病结果的研究.

主要成果:

早期的术后精神病学AE在PD的DBS中很常见,通常在几天内出现,通常是短暂的.
调整DBS参数或精神病药物可以改善这些AE.
STN和GPi在情绪调节中发挥作用,而不仅仅是运动控制.

结论:

对患有PD的DBS患者来说,监测精神病学的结果至关重要.
需要提高对早期精神病并发症的认识和管理策略.
未来的研究应该标准化AE评估,并探索预防措施.

关键词:

电气刺激是一种电气刺激.冲动控制冲动控制这是一种神经外科手术.帕金森氏症是什么?精神病学在精神病学方面.

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