血清尿酸与肌素比率的增加与与脂肪性肝病相关的代谢功能障碍有关
Fang Wang1, XuDong Zheng1, Xiang Ni1
1Department of The Health Management Center, The First Affiliated Hospital of USTC: Anhui Provincial Hospital (South District), Hefei, 230001, Anhui, China.
Scientific reports
|July 24, 2025
概括
血清尿酸与肌素的比率 (SUA/SCr) 与代谢相关性肝病 (MASLD) 脂肪肝的严重程度正相关. 升高的SUA/SCr表明患MASLD的风险更高,并可能作为潜在的生物标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 生物标志物 生物标志物
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢相关性肝病 (MASLD) 是一个日益严重的健康问题.
- 确定可靠的生物标志物来确定MASLD的严重程度和发病率至关重要.
研究的目的:
- 调查血清尿酸与肌素比率 (SUA/SCr) 和MASLD中的肝硬化症严重程度之间的相关性.
- 评估SUA/SCr对MASLD发病率的预测值.
主要方法:
- 利用控制减弱参数 (CAP) 的短暂弹性图 (TE) 来评估34,981名个体的肝肥胖症.
- 分析了SUA/SCr和CAP价值之间的关联.
- 对2179名没有MASLD的个人进行了33个月的随访,以根据SUA/SCr水平评估MASLD发生率.
主要成果:
- 在SUA/SCr和CAP之间发现了显著的正相关性 (P < 0.0001),表明脂肪肝严重程度增加,SUA/SCr更高.
- SUA/SCr显示了MASLD发展的预测值 (P < 0.001).
- 较高的SUA/SCr水平与随访队列中MASLD累积发病率显著增加有关 (P = 0.0008).
结论:
- 升高的SUA/SCr水平与MASLD中更严重的肝肥胖症有关.
- SUA/SCr是MASLD发展的独立风险因素和预测因素.
- SUA/SCr可能是MASLD的有用生物标志物,需要进一步验证并与其他标志物结合使用.
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