早期的逆境改变了大脑结构,增加了对心理健康障碍的易感性
Charles A Nelson1,2,3, Eileen F Sullivan4,5, Viviane Valdes4,5
1Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Department of Paediatrics, Boston Children's Hospital, Boston, MA, USA. charles.nelson@childrens.harvard.edu.
Nature reviews. Neuroscience
|July 24, 2025
概括
早期的生活逆境,包括虐待和不安全的环境,显著影响儿童的大脑发育和心理健康. 这篇综述详细介绍了这些不良经历如何影响大脑电路,增加晚年精神健康障碍的风险.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 全球每年有数以百万计的儿童在早期生活中遇到逆境.
- 不良的童年经历包括虐待,不安全的社区和目击暴力.
- 这些经历会对大脑发育和心理健康产生负面影响.
研究的目的:
- 阐明早期逆境如何影响大脑架构和电路.
- 解释早期逆境,大脑发育和以后的精神健康障碍之间的联系.
- 审查早期不良体验对心理健康的后果.
主要方法:
- 审查涉及动物,非人类灵长类动物和人类模型的研究.
- 神经成像研究的分析.
- 检查经验依赖的出生后大脑发育,包括关键时期.
主要成果:
- 早期的逆境改变了大脑电路和神经网络的发展.
- 对不良体验的脆弱性在特定的发育时期 (关键时期) 增加.
- 早期的不良经历与增加对精神健康障碍的易感性有关.
结论:
- 提出了一个概念模型,将早期的逆境与以后的心理健康结果联系起来.
- 了解早期逆境对大脑发育的影响对于心理健康至关重要.
- 建议未来的研究方向进一步探索这一途径.
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