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Updated: Sep 14, 2025

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将LINE1插入NACC2位点会破坏HDM2轴,并激活肺癌原体信号传递

Pasano Bojang1, Yingshan Wang2, Kenneth S Ramos3,4

  • 1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.

NPJ precision oncology
|July 24, 2025
PubMed
概括

异常的LINE-1逆转移素在肺癌细胞中的活性向NACC2基因,影响HDM2/TP53/RB通路. 这一发现揭示了对肺癌遗传学和进展的新见解.

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