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Updated: Sep 14, 2025

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USP1-WDR48二基因酶复合体作为调节瘤相关巨细胞激活和抗瘤反应的分子开关起作用

Dianwen Han1, Lijuan Wang2, Shan Jiang1

  • 1Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Cell death and differentiation
|July 24, 2025
PubMed
概括

USP1-WDR48复合体控制着M2型瘤相关巨细胞 (TAMs) 的激活,这对癌症进展至关重要. 抑制这种复合体和CD47/SIRPα显示出协同的抗瘤效应,提供了新的乳腺癌治疗策略.

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