运动饮食干预改善但未能完全逆转肥胖引起的卵巢功能障碍:证据涵盖毛囊发育到胚胎发育的证据
Chen Xinyan1, Yu Ting1, Zhang Xi1
1Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, PR China.
Journal of ovarian research
|July 24, 2025
概括
肥胖会损害女性的生育能力,因为通过线粒体功能障碍和破坏信号通路,会损害卵巢储备和卵细胞质量. 运动和饮食干预部分恢复生殖功能,但不能完全逆转肥胖引起的卵巢衰老.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 代谢性疾病 代谢性疾病
背景情况:
- 肥胖是一个全球性的健康问题,它会对全身平衡和女性生殖能力产生负面影响.
- 脂肪组织功能障碍影响卵巢储备的确切机制尚不完全理解.
研究的目的:
- 在小鼠模型中研究肥胖对卵巢储备和卵细胞质量的影响.
- 评估联合运动和饮食干预措施在减轻肥胖相关生殖缺陷方面的有效性.
主要方法:
- 使用高脂肪饮食 (HFD) 诱导的肥胖小鼠模型和运动-饮食干预 (SE组).
- 进行了卵巢组织形态学,传输电子显微镜 (TEM),超排卵试验,免疫光和西部斑分析.
主要成果:
- HFD小鼠显示卵巢缩,卵泡缩增加,卵泡数量减少,在SE组中部分恢复.
- 肥胖导致线粒体功能障碍,高反应性氧物种 (ROS),卵细胞成熟受损,以及异常的线组装.
- HFD降低了关键的毛囊生成调节者 (例如,BMP-15,HIF-1α) 的调节,并破坏了PTEN/AKT/FoxO3信号通路,同时增加了代谢应激标志物.
结论:
- 肥胖导致双重卵巢功能障碍:线粒体-ROS功能障碍影响卵细胞能力和BMP-15/HIF-1α抑制影响卵泡存活.
- 运动与饮食的联合干预显示出改善肥胖女性代谢参数和卵细胞质量的潜力,尽管一些损害可能是不可逆转的.
- 肥胖是卵巢衰老的驱动因素,这强调了生活方式干预对生育能力的保护的重要性.
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