神经肌肉运动除了单独治疗症状和放射性膝关节骨关节炎的赛莱科西布相比:一个随机对照试验
Xiaotian Yang1, Haixin Song2, Xuqing Li2
1Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No.3 East Qingchun Road, Hangzhou, 310016, China. xiaotian.yang@zju.edu.cn.
BMC sports science, medicine & rehabilitation
|July 24, 2025
概括
结合神经肌肉运动 (NEXA) 与赛莱科西布,可显著改善膝关节骨关节炎患者的疼痛和身体功能. 这种组合疗法与单独使用赛莱科克西布相比,在控制膝关节OA症状方面具有有益的效果.
科学领域:
- 整形外科 整形外科 整形外科
- 康复医学 康复医学 康复医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 膝关节骨关节炎 (OA) 是一种普遍的疾病,影响着全球数百万人.
- 神经肌肉运动 (NEXA) 和赛莱科克西布都已成为膝关节OA的治疗方法.
- 在膝关节OA管理中,将NEXA与赛莱科西布结合使用的协同效应仍然不完全理解.
研究的目的:
- 为了评估 NEXA 和 celecoxib 联合治疗与 celecoxib 单一治疗的疗效.
- 评估症状和放射性膝关节OA患者对疼痛和身体功能的影响.
主要方法:
- 一个前性的,评估者盲目的,优越性随机对照试验,涉及60名参与者,他们患有Kellgren和Lawrence 2-3级膝关节OA.
- 参与者被随机分配到12周的NEXA加上赛莱科西布或单独赛莱科西布.
- 主要结局包括视觉模拟尺度 (VAS) 和西安大略省和麦克马斯特大学骨关节炎指数 (WOMAC) 在6个月的得分.
主要成果:
- 组合组在6个月后显示出VAS和WOMAC总得分的统计学上显著改善.
- 在KOOS亚尺度,6分钟步行测试和定时启动和启动 (TUG) 测试中观察到组合治疗的优越性.
- 组合组中较高比例的患者在WOMAC分数中实现了临床上较少的重要差异.
结论:
- 神经肌肉运动 (NEXA) 除了塞莱科克西布外,还表明对疼痛和身体功能有有益影响.
- 组合疗法优于单独使用赛莱科西布来治疗6个月后症状和放射性膝关节OA.
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