神经纤维光链和残疾措施作为早期多发性硬化症认知衰退的预测因素
Vera Taluntiene1, Natasa Giedraitiene1, Rasa Kizlaitiene1
1Clinic of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
概括
脑脊液 (CSF) 和血清神经丝光链 (NfL) 水平,结合身体功能测试,可以预测早期MS患者的认知障碍. 这些生物标志物有助于识别面临认知衰退风险的个体.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 神经学 神经学
背景情况:
- 多发性硬化症 (MS) 与轴突退化有关,由神经丝光链 (NfL) 水平表示.
- 认知障碍 (CI) 是MS患者常见和致残的症状.
- 在MS中早期发现CI对于及时干预和管理至关重要.
研究的目的:
- 调查脑脊液 (CSF) 和血清NfL水平对新诊断的MS患者认知障碍的预测值.
- 评估NfL生物标志物和身体功能测量 (手工敏捷性,行走) 在预测MS相关CI的综合实用性.
- 在多发性硬化症的早期阶段建立可靠的认知衰退预测因子.
主要方法:
- 分析了99名新诊断的MS患者和37名健康对照组的队列.
- 测量了CSF和血清NfL水平;用MS简要国际认知评估 (BICAMS) 电池评估认知功能.
- 使用扩展残疾状况尺度 (EDSS),九孔测试 (NHPT) 和定时25英尺步行测试 (T25FWT) 评估残疾.
主要成果:
- 与对照人群相比,MS患者的认知分数较低,NHPT和T25FWT的表现较差,血清NfL水平较高.
- 在32.3%的MS患者中发现认知障碍.
- 较低的CSF NfL水平预测了更好的视觉空间记忆 (BVMT-R),而NHPT和T25FWT时间预测了SDMT和BVMT-R的损伤.
结论:
- 脑流和血清NfL度,以及手动敏捷度和行走度,是早期MS认知障碍的有价值预测指标.
- 这些生物标志物和功能测试可以帮助识别患有认知衰退风险的多发性硬化症患者.
- 这些发现支持使用NfL和物理评估来早期检测和管理MS的认知问题.
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