被诊断为自闭症谱系障碍的儿童的营养状况:系统性审查和元分析
Afnan Alhrbi1, Dimitris Vlachopoulos1, Ellie-Mae Healey1
1Children's Health and Exercise Research Center, University of Exeter, Exeter, Devon.
概括
患有自闭症谱系障碍 (ASD) 的儿童比通常发育的儿童 (TDC) 矮,这与较低的蛋白质和维生素摄入量有关. 在ASD中营养状况需要进一步调查.
科学领域:
- 营养科学 营养科学
- 发育儿科 发育儿科
- 自闭症研究 自闭症研究
背景情况:
- 自闭症谱系障碍 (ASD) 可以影响养行为,可能影响身体发育.
- 营养状况是儿童整体健康和发展的关键因素.
研究的目的:
- 将ASD儿童的营养状况与典型发育儿童 (TDC) 的营养状况进行比较.
- 检查这些群体之间的人类学,微量营养素状况和饮食摄入量的差异.
主要方法:
- 一项对32项涉及18480名儿童的研究的元分析 (2955名患有自闭症,15525名TDC).
- 搜索的数据库:PubMed,科学网,Scopus,以及CENTRAL. 这些数据库都是搜索的.
- 使用标准化平均差异 (SMD) 和风险比率 (RR) 进行统计分析.
主要成果:
- 患有自闭症儿童的TDC显著低于TDC (SMD: -0.16).
- 在患有自闭症的儿童中观察到蛋白质和几种维生素 (A,D,K,叶酸, рибофлавин,胺,尼亚) 的摄入量减少.
- 在患有自闭症儿童中,发现了维生素D和叶酸等微量营养素的较低水平.
结论:
- 与TDC相比,患有自闭症儿童的身高较小,可能是由于蛋白质和维生素摄入量和状态较低.
- 这些发现凸显了对ASD的营养状况进行进一步纵向研究的需要.
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