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Updated: Sep 14, 2025

Capillary Electrophoresis to Monitor Peptide Grafting onto Chitosan Films in Real Time
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在生物配方开发中研究弱聚-环极的相互作用,使用亲和毛细血管电泳和流动诱导分散分析

Yunxiao Zhu1, Sharadvi Thati1, Megan Mccallum1

  • 1Drug Product Development, Bristol-Myers Squibb, New Brunswick, New Jersey, USA.

Electrophoresis
|July 25, 2025
PubMed
概括

硫丁乙-β-环氧化 (SBE-β-CD) 与基乙-β-环氧化 (HP-β-CD) 相比,对放松素 (RLX) 的亲和力更高. 这些发现有助于选择辅助剂以提高生物制药溶解度和药理动力学.

关键词:
亲近性毛细血管电泳 (ACE) 的研究.具有约束力的循环德克斯特林.流量诱导的分散分析 (FIDA)这是一种多类聚.

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
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Electrophoresis is a powerful analytical separation technique that relies on the differential migration of charged species when subjected to an electric field. The core strength of electrophoresis lies in its ability to separate high-molecular-weight species in complex mixtures. It has found widespread use in biochemistry, molecular biology, and analytical chemistry, allowing the separation of compounds like amino acids, nucleotides, carbohydrates, and proteins with excellent resolution.
There...
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Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
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Affinity Chromatography01:03

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Affinity chromatography is a powerful technique extensively utilized for separating and purifying specific biomolecules from complex mixtures. It capitalizes on the highly selective binding between an analyte and its counterpart, such as antibody-antigen interactions. The counterpart is immobilized on the stationary phase, forming an affinity column. The stationary phase typically consists of solid support, such as agarose or porous glass beads, immobilizing the affinity ligand. The mobile...
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