在REGARDS中,可溶性受体用于先进的糖化终端产品和事件高血压
Sarah D R Krumholz1, Mary Cushman1, Nels C Olson1
1Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
American journal of hypertension
|July 25, 2025
概括
对于高级糖化终产品 (sRAGE) 的更高可溶性受体与黑人或白人成年人的高血压风险降低无关. 低SRAGE可能表明炎症,高血压驱动器,而不是导致高血压本身.
科学领域:
- 心血管健康 心血管健康
- 生物标志物和疾病风险
- 健康方面的种族差异.
背景情况:
- 美国黑人成年人面临着更高的高血压负担和更低的可溶性受体对高级糖化终产品 (sRAGE) 水平.
- sRAGE的抗炎性质表明它可能在高血压的发展中起作用.
- 这项研究调查了不同队列中sRAGE水平与事件高血压风险之间的关联.
研究的目的:
- 为了确定更高的基线sRAGE水平是否与患高血压的风险降低有关.
- 检查美国不同种族群体之间的这种关联.
主要方法:
- 利用了来自研究中风的地理和种族差异原因 (REGARDS) 的数据,其中包括4400名参与者参加了两次访问.
- 使用ELISA在没有流行高血压的参与者中测量了基线sRAGE水平.
- 采用波桑回归来通过sRAGE四分位数估计发生高血压风险比率 (RR),并对混因素进行调整.
主要成果:
- 在没有基线高血压的1,799名参与者中,46%的黑人和31%的白人参与者患有高血压.
- 与白人参与者相比,黑人中的中位数sRAGE水平明显较低.
- 在白人参与者中,较高的sRAGE四分位数在最小调整的模型中显示出较低高血压风险的趋势,但在完全调整后,这种关联消失了. 在黑人参与者中没有发现任何关联.
结论:
- 在这个队列中,较高的基线sRAGE水平与较低的事件高血压风险没有独立相关.
- 低SRAGE可能反映了导致高血压的潜在炎症,而不是直接原因.
- 需要进一步的研究来阐明炎症,sRAGE和高血压发展之间的复杂相互作用,特别是跨种族群体.
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