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美国成年人血清总胆红素和潜在肥胖指数之间的横截面数据分析
Libing Tian1, Jian-Gang Zhang2, Yanshen Chen3
1College of Chemical Engineering, Huaqiao University, Xiamen, China.
Current molecular medicine
|July 25, 2025
概括
血清总 bilirubin (STB) 水平与内脏肥胖指标 (如 VAI 和 LAP) 有负相关性. 这表明胆红素可能在体脂分布和脂质代谢中发挥作用,特别是在特定的成年人群中.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 生物标志物研究 生物标志物研究
背景情况:
- 肥胖是代谢和心血管疾病的关键风险因素.
- 像内脏肥胖指数 (VAI) 和脂质积累产物 (LAP) 这样的内脏肥胖指数是评估内脏肥胖的新兴生物标志物.
- 血清总 bilirubin (STB),一种内源性抗氧化剂,已经证明对各种疾病有保护作用.
研究的目的:
- 为了研究血清总胆红素 (STB) 水平和成年人内脏脂肪指数 (VAI和LAP) 之间的关系.
- 探索STB和内脏肥胖的标志物之间的潜在相关性.
- 为了确定胆红素在体内脂肪分布和脂质代谢中的作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) (2003-2020) 的横截面数据.
- 采用加权多变量回归模型和受限立方斜线 (RCS) 曲线来分析关联.
- 进行了子组分析,以检查人口特异性的异质性.
主要成果:
- 分析了10625名年龄在20-85岁之间的成年人的队列.
- 在调整后的模型中,在STB水平和VAI和LAP之间发现了显著的负相关性 (P<0.001).
- 通过RCS证实了线性关系,在没有高血压或糖尿病的20-59岁非吸烟者中观察到更强的关联.
结论:
- 血清总白血素 (STB) 与美国一般人口的内脏脂肪指数 (VAI/LAP) 有显著的关联,特别是在年轻,更健康的成年人中.
- 这些发现凸显了胆红素作为与身体脂肪分布相关的早期代谢风险标志物的潜在作用.
- 需要进一步的前性研究来阐明STB和新型肥胖指数之间的时间关系.
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