慢性后COVID神经精神症状在"Omicron波"期间感染后持续超过1年
Steven Wai Ho Chau1,2, Timothy Mitchell Chue1, Tsz Ching Lam1
1Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR.
经COVID-19 Omicron感染后的慢性神经精神病症状分为认知疲劳和焦虑抑郁组. 患者的表型与感染前的剥夺,急性COVID严重程度和先前的心理健康状况有关,而不是疫苗接种状态.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 传染性疾病 传染性疾病
背景情况:
- 慢性后COVID神经精神症状 (PCNPS) 异质性,特别是在Omicron感染后,需要进一步调查.
- 了解症状集群和患者表型对于管理长期COVID至关重要.
研究的目的:
- 探索症状集群,并确定患有慢性PCNPS的患者表型,这些患者在Omicron波中感染.
- 用预先注册的协议分析预测这些表型的因素.
主要方法:
- 评估了1205名香港参与者在Omicron浪潮期间首次感染COVID-19.
- 利用基于应用程序的问卷和认知任务来评估症状.
- 应用部分网络分析来识别症状集群和后勤回归来确定预测因素.
主要成果:
- 确定了两个主要的症状集群:认知抱怨-疲劳和焦虑-抑郁症,以及一个轻微的头痛-头集群.
- 发现了两个不同的患者表型:认知投诉-疲劳占主导地位和多集群症状呈现.
- 感染前的剥夺预测了这两种表型. 急性COVID严重程度和先前存在的疾病预测了认知疲劳表型,而过去的自杀念头预测了多集群表型. 疫苗接种状态不是一个预测因素.
结论:
- 建议采用表型驱动的生物心理社会方法来管理异构的PCNPS.
- 基于已识别的表型进行分层的患者管理至关重要.
- 临床医生必须认识到,仅抑郁和焦虑并不能解释所有慢性后COVID认知症状.
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