新生儿通过肠道营养暴露于酸盐和替代性可塑剂
Paulien Cleys1, Lucas Panneel2,3, Philippe G Jorens3,4
1Toxicological Centre, University of Antwerp, Universiteitsplein 1, Wilrijk 2610, Belgium.
Environmental science & technology
|July 25, 2025
概括
过早出生的婴儿可能会超过安全的甲酸盐暴露限值,原因是配方奶,而不是塑料养管. 三2-乙烯基) 三化物 (TOTM) 的迁移率较低,为塑料医疗器械提供更安全的替代品.
科学领域:
- 环境健康 环境健康
- 分析化学 分析化学
- 新生儿医学 新生儿医学
背景情况:
- 新生儿重症监护室 (NICU) 使用塑料医疗器械 (PMD) 进行肠道营养 (EN).
- PMDs可以出甲酸盐和替代性塑化剂 (AP),对脆弱的新生儿构成风险.
- 了解暴露源对于婴儿的健康和安全至关重要.
研究的目的:
- 在用于新生儿EN的PMD中识别和量化酸盐和AP.
- 用于测量人乳和配方奶中的甲酸盐和AP度.
- 为了评估模拟新生儿EN给药过程中PMDs的出.
主要方法:
- 使用液体染色学-并联质谱学 (LC-MS/MS) 和气体染色学-质谱学 (GC-MS) 分析了19个PMD.
- 在35个母乳和23个配方奶样品中量化了酸盐,AP和代谢物.
- 模拟体内新生儿内肠道注射的ex vivo漏实验.
主要成果:
- 三二甲基三甲酸 (TOTM) 和二二甲基甲酸 (DEHP) 是PMD中占主导地位的增塑剂 (胃管中质量度高达0.45%).
- 在配方奶中检测到了酸盐 (DiBP,DEHP,DINP,DIDP) 和AP (ATBC,DEHA,DINCH).
- 单纯的配方奶,而不是PMD液,可能导致甲酸盐暴露高达欧洲化学品署推导无效水平 (DNEL) 的三倍.
结论:
- 配方奶是早产新生儿甲酸盐和AP暴露的重要来源.
- 在肠道养期间,塑料管中的液是导致整体暴露的小因素.
- TOTM的低迁移潜力为减少新生儿暴露在有害塑化剂中的机会提供了机会.
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