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结核的抗糖尿病潜力:探索植物化学物质,选抗氧化活性和验证DPP-4抑制使用体外和体内方法
Ilham Khan1, Shabana Bibi2, Junaid Shehzad1
1Department of Plant Sciences, Faculty of Biological Sciences Quaid-i-Azam University Islamabad Pakistan.
Food science & nutrition
|July 25, 2025
概括
这项研究证实了传统药用植物Afteranthes tuberculata的抗糖尿病潜力. 它的提取物显示出显著的抗氧化剂和二乙酶-4 (DPP-4) 抑制活性,表明作为天然糖尿病治疗的承诺.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 代谢学 代谢学 代谢学
背景情况:
- 糖尿病是一种全球性的健康问题,由合成药物管理,具有潜在的副作用.
- 结核在巴基斯坦传统上用于糖尿病,但缺乏科学验证.
- 这项研究调查了A. tuberculata的抗糖尿病特性.
研究的目的:
- 为了评估A. tuberculata甲醇提取物的植物化学成分.
- 为了评估其体外抗氧化剂和二乙酶-4 (DPP-4) 抑制活性.
- 使用计算工具识别生物活性化合物及其与DPP-4的相互作用.
主要方法:
- 对全和黄的植物化学分析.
- 在体外抗氧化剂测定 (总抗氧化剂容量,降解功率,DPPH测定).
- DPP-4抑制试验,里埃变换红外光谱 (FTIR),液态染色体质谱 (LC-MS) 和计算建模.
主要成果:
- 提取物显示出大量的和黄,强大的抗氧化能力和DPPH激素清除活性.
- FTIR证实了碳水化合物和糖化物的存在.
- 提取物表现出显著的DPP-4抑制活性 (IC50 = 46.761μg/mL),与西塔格利普丁相当,LC-MS确定了24种生物活性化合物,包括强大的DPP-4抑制剂.
结论:
- 结核甲虫 (Apteranthes tuberculata) 具有显著的抗氧化和DPP-4抑制特性.
- 已识别的生物活性化合物,特别是黄和糖化物,有助于其抗糖尿病潜力.
- 结核菌 (A. tuberculata) 显示出作为糖尿病管理的天然治疗剂的前景.
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