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Updated: Sep 14, 2025

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
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Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

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多轴旋转负荷损害了椎间盘的过渡区域:使用下一代生物反应器的ex vivo研究

Amra Šećerović1, Aapo Ristaniemi1, Francesco Crivelli2

  • 1AO Research Institute Davos Davos Switzerland.

Bioengineering & translational medicine
|July 25, 2025
PubMed
概括

新的生物反应器模拟复杂的脊柱运动,揭示了多轴负荷加速磁盘退化. 扭转加剧了矩阵分解和细胞死亡,突出了过渡区作为关键的早期损伤地点.

关键词:
生物反应器的生物反应器椎间盘之间的椎间盘.多轴负载的多轴负载.过渡区的过渡区整体器官培养 整体器官培养

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相关概念视频

Normal Strain under Axial Loading01:20

Normal Strain under Axial Loading

Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
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Eccentric Axial Loading in a Plane of Symmetry01:16

Eccentric Axial Loading in a Plane of Symmetry

Eccentric axial loading occurs when an axial load is applied away from the centroidal axis of a structural member. This scenario is common in engineering, where structural elements may not be directly aligned due to various design or functional requirements.
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General Case of Eccentric Axial Loading01:12

General Case of Eccentric Axial Loading

Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
248