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在LIFR基因中单个核酸多态的关联分析与绵羊的羔羊数

Yuliang Wen¹, Yuping Xiang^1,2, Runan Zhang²

¹College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.

Frontiers in veterinary science

|July 25, 2025

概括

白血病抑制因子受体 (LIFR) 基因中的遗传标记,特别是c.127 T>C位点,与绵羊的羔羊数量有关. 这一发现提供了一个潜在的遗传工具,用于提高多种菌性绵羊品种的繁殖效率.

科学领域:

动物遗传学动物遗传学
生殖生物学生殖生物学
量化遗传学量化遗传学

背景情况:

羊群数量是绵羊生产中的关键经济特征,受多个基因的影响.
诸如SPOCK1,ADAMTS1,HBEGF和LIFR之类的基因已涉及哺乳动物的繁殖,但它们在绵羊羔羊数量中的具体作用尚不清楚.

研究的目的:

研究SPOCK1,ADAMTS1,HBEGF和LIFR基因中单核酸多态化 (SNP) 位点与绵羊的羔羊数的关联.
确定潜在的基因标记物,以提高绵羊群中的羔羊发育率.

主要方法:

在使用Sequenom MassARRAY SNP试验的五种品种的768只羊中,对四个候选基因 (SPOCK1,ADAMTS1,HBEGF,LIFR) 的六个SNP位点进行基因定型.
种群遗传分析和确定SNP与羔羊数量之间的关联分析,特别是在小尾汉羊群中.

主要成果:

在四个基因中确定了六个SNP,在所有品种中观察到三种基因型.
在LIFR基因中的c.127 T>C位点与小尾汉羊的羔羊数量有显著的关联.
与TT和CT基因型相比,LIFR CC基因型的母羊的羔羊数量显著下降.

结论:

在LIFR基因中的c.127 T>C多态性是影响小尾汉羊羔数量的重要遗传因素.
这种LIFR位点可以作为标记器辅助选择的候选遗传标记物,以改善繁殖特征并增加多菌羊的羔羊数量.

关键词:

根据LIFR的规定.马萨拉雷 (MassARRAY) 是一个羊羔号码羊羔号码分子标记物是分子标记物.羊群羊群羊群的羊群是什么意思

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