通过核心受体的使用在艾滋病毒-1感染者中发生炎症和免疫激活的模式
Francisco Xavier Guerra-Castillo1,2, Sandra Pinto-Cardoso3, Santiago Ávila-Ríos3
1Unidad de Investigación Médica en Inmunología e Infectología, Hospital de Infectología "Dr. Daniel Méndez Hernández", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México, Mexico.
Frontiers in immunology
|July 25, 2025
概括
在晚期的HIV-1感染中,R5变体与较高的IL-6相关,而X4变体与免疫激活有关. 升高的IL-6预测较少的X4病毒,这表明疾病进展中的复杂相互作用.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 人类免疫缺陷病毒1型 (HIV-1) 的进入取决于CCR5 (R5) 或CXCR4 (X4) 核心受体.
- 核心受体切换到X4和免疫激活与HIV-1疾病进展有关.
- X4-热带HIV-1在晚期感染的慢性激活免疫环境中壮成长.
研究的目的:
- 为了确定墨西哥城未接受治疗的晚期HIV-1呈现者的病毒热带性.
- 为了研究病毒热带和慢性免疫激活标志物之间的关系.
主要方法:
- 对122名艾滋病毒感染者 (PLWH) 的横截面研究.
- 病毒热带性通过下一代测序 (NGS) 和 geno2pheno算法进行评估.
- 免疫激活标志物 (流细胞计,sCD14,sCD163,IL-6的ELISA) 的量化.
主要成果:
- 在98个高质量序列的个体中,有18.4%的个体具有X4或混合R5/X4变异.
- 升高的IL-6水平与R5变异显著相关 (p=0.01).
- X4 变种显示出 CD38+ 和 HLA-DR+CD38+表达增加的趋势;IL-6 是 X4 病毒的负预测因子 (OR=0.06,p=0.006).
结论:
- R5-热带病毒与IL-6的升高有关,这表明炎症反应.
- X4-热带病毒可能通过免疫激活导致CD4+T细胞枯竭.
- 艾滋病毒-1热带和慢性免疫激活之间的相互作用是复杂的,可能是双向的.
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