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在心房动中,心房纤维化和炎症之间的相互作用

Zhihua Pang¹, Ying Ren¹, Zhuhua Yao¹

¹Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.

Frontiers in cardiovascular medicine

|July 25, 2025

概括

心房纤维化和炎症通过复杂的途径驱动心房动 (AF). 针对这些机制的新型疗法,以及先进的成像,可能会改善AF管理.

科学领域:

心脏病学心脏病学
病理生理学病理生理学
生物医学工程生物医学工程

背景情况:

心房动 (AF) 是一个复杂的疾病,纤维化和炎症是主要的驱动因素.
雷宁- ангиотензин-алдостерон系统 (RAAS),TGF-β/Smad和细胞因子级联 (TNF-α/NF-κB,IL-6/STAT3) 在AF中促进纤维细胞重塑和电生理功能障碍.
目前的AF治疗重点是通过切除和抗失律药物控制节律,但抗炎疗效尚不确定.

研究的目的:

审查心房纤维化和炎症在AF中的病理生理学作用.
为了检查心房纤维化和AF进展中的炎症之间的双向关系.
引导开发用于AF管理的新型治疗干预措施.

主要方法:

对AF病理生理学的现有文献进行系统审查.
对关键分子通路 (RAAS,TGF-β/Smad,细胞因子级联) 涉及纤维化和炎症的分析.
评估先进的纤维化量化技术 (LGE-MRI,EAM) 和它们在废除策略中的作用.

主要成果:

前庭纤维化和炎症是AF启动和延续的核心,为维护创造了基质.
像LGE-MRI和EAM这样的先进成像技术有助于优化切除策略.
新出现的证据表明纤维化和基质的性别差异,暗示性别特异性疗法.

结论:

了解心房纤维化和炎症之间的相互作用对于开发新的AF疗法至关重要.
先进的成像技术改善了个性化的切除策略.
对基于性别的差异进行进一步的研究可能会导致量身定制的AF治疗.

关键词:

这是心房心脏.心房动是心房动的一种.在心房纤维化.动是因为动.有纤维化的纤维化.这是一种炎症炎症炎症炎症.

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