甲状腺功能和多病性背景下的全因死亡率:来自两个基于人口的研究的结果
Yanning Xu1,2,3, Silvan Licher3,4, W Edward Visser1,2
1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
The Journal of clinical endocrinology and metabolism
|July 25, 2025
概括
较高的自由甲状腺素 (FT4) 水平与多病症患者的死亡风险增加有关. 相反,较低的自由三甲状腺素 (FT3) 水平与该人群中较差的生存结果有关.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 甲状腺功能障碍在老年人群中普遍存在,增加非传染性疾病的风险.
- 多种疾病,多种疾病的存在,可能会使甲状腺功能和死亡率之间的关系复杂化.
研究的目的:
- 在多病症的背景下,研究甲状腺功能与全因死亡率之间的关联.
主要方法:
- 利用了PREVEND和鹿特丹研究的数据,包括甲状腺功能测量和疾病状态.
- 将参与者分类为以下几组:没有疾病,一种疾病和多病症.
- 采用Cox比例危险模型来分析甲状腺功能和全因死亡率,报告甲状腺功能Z-score每单位增加的危险比率 (HRs).
主要成果:
- 在鹿特丹研究中,较高的自由甲状腺素 (FT4) 与所有疾病类别的死亡风险增加有关 (HRs从1.07到1.21).
- 在PREVEND研究中观察到类似的,但不显著的趋势.
- 较高的自由三甲氨酸 (FT3) 度与患有一种疾病 (HR 0.82) 和多种疾病 (HR 0.80) 的个体的死亡风险较低有关.
结论:
- 较高的FT4水平与多病症患者的死亡率增加有关.
- 较低的FT3水平与多病症患者的生存率较差有关.
- 这些发现扩展到具有多种疾病的一般人群中,并且需要对levothyroxine用户进行进一步的研究.
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