在早期发病的阿尔茨海默氏病与晚期发病的阿尔茨海默氏病中,有不同的炎症概况
Simrika Thapa1,2,3, Chloe Anastassiadis1,2, Anna Vasilevskaya1,2
1Tanz Centre for Research on Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
概括
神经炎症在年轻发病 (YOAD) 和晚发病 (LOAD) 的阿尔茨海默氏症 (AD) 中都加剧,但在YOAD中独特地导致AD病理和神经退行.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 神经炎症在阿尔茨海默氏病 (AD) 发病过程中起着至关重要的作用.
- 它的参与可能在年轻发病的AD (YOAD) 和晚发病的AD (LOAD) 之间有所不同.
研究的目的:
- 为了研究YOAD与LOAD的不同神经炎症特征.
- 探索这些AD亚型中神经炎症和神经退行症之间的关系.
主要方法:
- 利用奥林克的近距离延伸试验分析了脑脊液 (CSF) 中的737个炎症标志物.
- 与90名AD患者 (57名YOAD,33名LOAD) 和26名健康对照进行了比较.
- 评估了AD病理 (Aβ42,p-tau181,t-tau) 和神经退行 (NfL) 的生物标志物.
主要成果:
- 与对照组相比,YOAD和LOAD中的SCRN1和MMP10都增加了.
- 确定了16种炎症标志物,具有YOAD特异性增加.
- 发现tau在YOAD中调解了炎症和神经退行之间的联系,在LOAD中没有观察到这种联系.
结论:
- 蛋白质组学揭示了AD中恶化的神经炎症,在YOAD和LOAD中发挥着不同的作用.
- 神经炎症对阿尔茨海默病理和神经退行症的贡献在YOAD和LOAD之间是不同的.
- 这些发现突出了阿尔茨海默病潜在的亚型特定治疗点.
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