胎盘基因表达与早期儿童生长轨迹和肥胖风险相关
Hyo Young Choi1, Luhang Han1, Alison G Paquette2
1Department of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Obesity (Silver Spring, Md.)
|July 25, 2025
概括
胎盘基因表达与儿童生长模式和肥胖风险有关. 胎盘中的免疫系统基因可能在发展儿童肥胖症中发挥关键作用.
科学领域:
- 遗传学和发育生物学
- 儿科健康 儿科健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 儿童早期的成长轨迹和肥胖受复杂的遗传和环境因素的影响.
- 胎盘基因表达是胎儿发育的关键决定因素,可能会影响长期的健康结果.
- 了解早期生长的分子基础对于开发有效的肥胖预防策略至关重要.
研究的目的:
- 为了研究胎盘基因表达和早期儿童生长轨迹之间的关联.
- 确定与儿童肥胖风险相关的胎盘中的特定基因和生物通路.
- 使用孟德尔随机化探索胎盘基因表达和生长结果之间的潜在因果关系.
主要方法:
- 分析794名儿童的胎盘转录组数据,用于影响神经认知发育和早期儿童学习的条件研究.
- 鉴定与体重指数 (BMI) 轨迹和4岁时超重/肥胖相关的差异表达基因 (DEGs).
- 路径丰富分析和门德尔随机化 (MR) 探索生物路径和因果关系.
主要成果:
- 22和23个DEG分别与BMI轨迹和超重/肥胖相关 (错误发现率[FDR]<0.05).
- 途径分析揭示了26种生物途径,主要与免疫系统有关.
- 核磁共振分析表明,一个DEG与BMI轨迹以及八个DEG与超重/肥胖 (FDR<0.05) 的潜在因果关系.
结论:
- 胎盘基因表达与早期儿童生长轨迹和肥胖风险有关.
- 胎盘免疫系统中的基因可能是儿童肥胖症发展的重要贡献者.
- 这些发现强调了胎盘作为旨在预防儿童肥胖的干预措施的潜在目标.
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