环状皮质塑造了社会发声的早期产后发展
Gurueswar Nagarajan1, Denis Matrov1, Anna C Pearson1
1Section on Behavioral Neuroscience, National Institutes of Health, Bethesda, United States.
eLife
|July 25, 2025
概括
马尔莫塞特前带带皮层 (ACC) 的早期损伤扰乱了社交声乐的发展. 新生儿ACC病变改变了社交联系和通话质量以及下游大脑结构,影响了语音交流.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 灵长类动物学 灵长类动物学
背景情况:
- 社会发言对于社会发展至关重要.
- 前带带皮质 (ACC) 在社会情绪调节中发挥作用.
- 了解早期大脑发育对声乐行为的影响至关重要.
研究的目的:
- 调查前带状皮层 (ACC) 早期生命损伤对普通鱼社会发声的发展的影响.
- 为了确定ACC病变是否会影响语音呼叫的产生,质量和长期的神经变化.
主要方法:
- 新生儿常见海接收了ACC病变或作为对照.
- 在生命的前6周记录和分析了发声.
- 尸体分析检查了成年大脑区域 (杏仁体,水道灰) 的GABA免疫活性.
主要成果:
- 早期的ACC病变并没有显著影响基本的语音呼叫生产.
- 社交联系电话的质量,序列和声学特性受到损害.
- 受伤的动物会发出更少,更短,更大声,更单调的社交呼叫.
- 患有早期ACC损伤的成年动物在杏仁体和近水管灰细胞中显示GABA免疫活性减弱.
结论:
- 前带带皮质 (ACC) 对于社会声乐行为的正常发育轨迹至关重要.
- 早期的ACC损伤会导致声部通信和相关的神经通路的持久变化.
- 干扰ACC功能会影响下游声控区域的抑制平衡.
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