使用正负直接电刺激与休息状态功能性MRI绘制语音节网络的功能边界
Lara Maria Viola1, Manuela Moretto1, Luca Zigiotto2,3,4
1CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto (Trento) , Italy.
Neurosurgery
|July 25, 2025
概括
直接电刺激 (DES) - 负点通过静止状态功能性MRI (rs-fMRI) 完善语音发音网络 (SAN) 映射. 这提高了对质瘤患者功能性大脑区域识别的准确性.
科学领域:
- 神经成像是一种神经成像.
- 神经外科 神经外科
- 神经科学是一个神经科学.
背景情况:
- 休息状态功能性MRI (rs-fMRI) 在瘤学中越来越多地用于术前规划和脑图绘制.
- 在清醒时进行手术的直接电刺激 (DES) 是识别功能性大脑区域的黄金标准.
- 之前使用rs-fMRI对语音发音网络 (SAN) 的映射主要集中在DES阳性点上.
研究的目的:
- 整合积极和消极的DES数据,以创建一个更全面的SAN地图.
- 通过在质瘤患者中使用术前功能连接来完善SAN的功能边界.
- 探索DES-负点在改进基于rs-fMRI的大脑绘图中的实用性.
主要方法:
- 对25名质瘤患者 (16名高度,9名低度) 的分析,这些患者接受了使用DES映射的清醒手术.
- 在灰色物质中识别了74个DES点 (32个正点,42个负点).
- 对手术前 rs-fMRI 数据进行基于种子的连接性分析,单独分析正负 DES 点.
主要成果:
- 阳性DES的SAN位于双边的罗兰 operculum,下额头环和上环.
- 负DES点显示出明显的连接模式,有助于划分SAN功能边界,特别是在中央和下额头周附近.
- 对于SAN阳性网络的41%值,实现了大约80%的特异性和灵敏性.
结论:
- 积极的DES点强烈地定义了SAN.
- 对于建立值和完善组SAN图谱的功能边界而言,DES负点至关重要.
- 整合积极和消极的DES数据可以提高基于rs-fMRI的功能性脑图的精度.
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