英国哥伦比亚省 (BC) 新诊断的严重大动脉狭窄症的性别差异
Aishwarya Roshan1,2, Jeffrey Yim2,3, Shamikh Lakhani1
1Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Diseases (Basel, Switzerland)
|July 25, 2025
概括
患有严重大动脉狭窄症 (AS) 的女性晚些时候被诊断出来,并且不太可能接受大动脉置换 (AVR). 他们面临更高的死亡率和住院率,这表明基于性别的管理差异很大.
科学领域:
- 心脏病学 心脏病学
- 心血管医学 心血管医学
- 医学研究 医学研究
背景情况:
- 大动脉狭窄 (AS) 很普遍,但其管理和结果的性别差异仍未得到充分研究.
- 了解这些差异对于公平的患者护理至关重要.
研究的目的:
- 调查性别对严重主动脉狭窄症 (AS) 的评估和治疗的影响.
- 为了比较结果,包括发病率和死亡率,在异性之间进行大动脉置换 (AVR) 后.
主要方法:
- 在2012年至2022年期间,对1794名被诊断患有严重AS的患者进行了回顾性图表审查.
- 使用奇平方和克鲁斯卡尔-瓦利斯测试进行统计分析,以根据性别比较患者的特征和结果.
主要成果:
- 女性在诊断时年龄较大,不太可能被评估或接受AVR (手术和透导管).
- 由于年龄,并发症和脆弱性,女性面临更高的AVR排斥率.
- 女人经历了显著更高的一年死亡率,住院和心力衰竭住院率.
结论:
- 在AS管理中存在显著的基于性别的差异,女性被诊断晚,接受的干预较少.
- 女性不成比例地受到年龄,虚弱和并发症的影响,导致AVR率较低.
- 需要进一步的研究,以确保所有患者,特别是女性,及时和适当地转诊AVR.
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