在乳腺癌微环境中,氨酶系统和巨细胞的作用
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Abir Abdullah Alamro1, Moudhi Abdullah Almutlaq1, Amani Ahmed Alghamdi1
1Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Diseases (Basel, Switzerland)
|July 25, 2025
概括
ангиотензин II (Ang II) 影响瘤相关巨细胞 (TAMs),改变它们的两极化和分泌. 这在瘤微环境 (TME) 中对MCF-7和MDA-MB-231细胞系的乳腺癌细胞生长有不同的影响.
科学领域:
- 免疫学和癌症生物学
- 分子内分泌学分子内分泌学
- 瘤微环境研究 研究
背景情况:
- 氨酸-血管素系统 (RAS) 调节血压和心血管平衡.
- 新出现的证据将RAS,特别是血管新生素II (Ang II) 与各种癌症联系起来.
- 瘤相关巨细胞 (TAMs) 在瘤发育和免疫反应中发挥着关键作用.
研究的目的:
- 研究Ang II在TAM和乳腺癌细胞之间的通信中的作用.
- 探索Ang II如何影响瘤微环境 (TME) 和其组成部分.
- 了解Ang II调节的TAMs对不同乳腺癌亚型的特定影响.
主要方法:
- 类似巨细胞的THP-1细胞被Ang II处理以产生条件介质.
- 条件介质应用于MCF-7和MDA-MB-231乳腺癌细胞系.
- 试验包括细胞增殖,迁移,极化,亡检测和反应性氧物种 (ROS) 生成.
主要成果:
- 在体外,Ang II促进了对M1 (促炎症) 和M2 (抗炎症) 现型的巨细胞两极分化.
- 格II,通过巨细胞,差异影响乳腺癌细胞系.
- 瘤生长和进展在MCF-7细胞中得到促进,但在MDA-MB-231细胞中受到抑制.
结论:
- 在TME中的Ang II调节TAM极化及其分泌因子.
- 这些TAMs的AngII诱导的变化对不同类型的乳腺癌细胞有不同的后果.
- 这项研究强调了Ang II在通过TAM相互作用调解乳腺癌进展中的复杂作用.
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