胃酸保护和肠道向的纳米凝使Cefquinome的抗菌活性成为可能
Xianqiang Li1, Tianhui Wang2, Shuo Han2
1College of Biomedicine and Health, Anhui Science and Technology University, Chuzhou 233100, China.
Gels (Basel, Switzerland)
|July 25, 2025
概括
一种使用碳甲基纤维素 (CMCNa) 和D-曼诺胺化物 (DMH) 的新型纳米凝输送系统通过持续的肠道释放增强了对大肠杆菌的抗菌活性.
科学领域:
- 纳米技术在药物输送中的应用
- 开发抗菌药物 开发抗菌药物
- 兽医药理学 兽医药理学 兽医药理学
背景情况:
- 塞夫昆 (CEF) 是一种抗生素,具有潜在的抗菌应用.
- 保护CEF免受胃分解,并确保有针对性的肠道释放,对于疗效至关重要.
- 开发先进的输送系统可以提高CEF的治疗特征.
研究的目的:
- 开发一种基于碳素甲基纤维素 (CMCNa) /D-曼诺胺化物 (DMH) 的纳米凝系统,用于 (CEF).
- 为了增强CEF对大肠杆菌的抗菌活性.
- 为了实现胃酸保护和持续的肠道释放CEF.
主要方法:
- 用于封装CEF的CMCNa/DMH纳米凝的配方.
- 纳米凝物理化学性质的表征,包括负载能力和封装效率.
- 评估稳定性,胃肠液响应性,以及对大肠杆菌的抗菌活性.
主要成果:
- 优化的CEF纳米凝显示出高负载能力 (13.0%±1.7%) 和封装效率 (52.2%±1.0%).
- 纳米凝表现出均的球形形态和稳定,多孔的结构.
- CEF纳米凝有效地保护了CEF免受模拟胃酸的影响,并证明在模拟的肠液中持续,有针对性的释放,导致与自由CEF相比,对大肠杆菌的抗菌活性提高.
结论:
- 开发的CMCNa/DMH纳米凝系统成功地保护CEF免受胃部降解.
- 纳米凝在肠道中提供持续和有针对性的CEF释放.
- 这种输送系统显著提高了CEF对大肠杆菌的抗菌疗效.
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