相关实验视频

Updated: Sep 13, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

药用凝介导结晶中的多态控制:利用FmocFF器官凝中的溶剂-凝剂协同作用

Dong Chen¹, Koen Robeyns², Tom Leyssens²

¹Department of Chemistry, Molecular Imaging and Photonics, KU Leuven, Campus KULAK Kortrijk, 8500 Kortrijk, Belgium.

Gels (Basel, Switzerland)

|July 25, 2025

概括

这项研究表明,FmocFF器官和溶剂选择如何控制尼胺结晶,产生新的多态. 研究人员使用基于乙尼的凝首次实现了对尼胺二型的环境隔离.

科学领域:

材料科学材料科学材料科学
结晶科学结晶科学
制药科学制药科学

背景情况:

FmocFF是一个多功能凝器,可以实现晶体工程.
尼卢胺表现出复杂的多态性,这对药物配方构成了挑战.
控制结晶路径对于制药固态特性至关重要.

研究的目的:

探索FmocFF有机体和溶剂选择对尼胺多态的协同效应.
为了实现受控的结晶,并发现新的尼胺固体形式.
建立凝介导结晶作为药物固体形式发现的平台.

主要方法:

在FmocFF有机凝中溶剂类型和度的系统变化.
使用诸如粉末X射线衍射 (PXRD),差分扫描热度计 (DSC),里埃变换红外光谱 (FTIR),单晶X射线衍射 (SXRD) 和第二子 (SHG) 显微镜等技术.
在不同的条件下研究晶体核和生长途径.

主要成果:

取得了对尼胺多态结局的显著控制.
据报道,使用基于乙尼的FmocFF器官凝,首次在环境温度下分离了纯尼胺II形式.
发现了一种具有第二子生成 (SHG) 活性的新型尼胺多态,表明了潜在的非中心对称性.
描述了一种以前未报告的尼胺-甲溶盐.

结论:

凝矩阵内的溶剂特异性分子识别允许进入新的多态空间.
凝介导结晶是一种强大且广泛适用的平台,用于在温和条件下发现制药固体形式.
这些发现突显了有机凝在控制药物多态性和发现新型固态形式方面的潜力.

关键词:

在FmocFF中,有机凝是晶体工程是什么意思水晶工程凝介导的结晶化过程尼胺胺是什么?尼胺是什么?制药中的多态生物.多态形态控制的控制方法酸盐溶剂的使用方法

更多相关视频

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels

Published on: September 8, 2016

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

相关概念视频

Crystal Growth: Principles of Crystallization

Crystal Growth: Principles of Crystallization

Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...

Recrystallization: Solid–Solution Equilibria

Recrystallization: Solid–Solution Equilibria

Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...