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通过口服暴露在斯普拉格 - 达利大鼠中的四种Per-和多基物质 (PFAS) 的亚慢性毒性

Elaina M Kenyon¹, Michael J Devito¹, Grace Patlewicz¹

¹Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Durham, NC 27709, USA.

|July 25, 2025

概括

这项研究研究了大鼠中的四种per-和多基物质 (PFAS) 的亚慢性毒性. 肝脏和脏的重量随着暴露于某些PFAS而增加,表明潜在的毒性.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
动物研究动物研究

背景情况:

和多基基物质 (PFAS) 是无处不在的环境污染物.
暴露于PFAS与不良健康影响有关,包括肝脏和甲状腺问题.
了解特定PFAS的毒理特征对于风险评估至关重要.

研究的目的:

为了评估四种特定的PFAS的亚慢性毒性:1H,1H,9H-perfluorononyl烯酸盐 (PFNAC),1H,1H,2H,2H-perfluorohexyl化物 (PFHI),甲基六烯酸 (MHFPK) 和2-chloro-2,3,3,3-tetrafluoropropanoic酸 (CTFPA).
为了确定90天口服暴露后斯普拉格-道利大鼠的剂量依赖效应和向器官.

主要方法:

在雄性和雌性Sprague-Dawley大鼠中进行了90天的口腔食研究.
暴露于四种不同的PFAS在不同的剂量水平.
评估临床症状,发病率,死亡率,器官重量和组织病理学.

主要成果:

对于PFNAC,PFHI和CTFPA,与肝细胞缩相关的相对和绝对肝体重的剂量依赖增加.
对于PFNAC和PFHI,分别观察到脏体重增加,这与管状上皮缩和慢性渐进性脏病有关.
MHFPK没有导致肝脏重量的显著变化,也没有观察到与化合物相关的对发病率,死亡率或明显毒性的影响.

结论:

在大鼠中,PFNAC,PFHI和CTFPA表现出剂量依赖的肝毒性.
此外,PFNAC和PFHI也表现出对脏的毒性.
在本次慢性研究中,MHFPK没有显示出显著的目标器官毒性.

关键词:

1H,1H,2H,2H- perfluorohexyl iodide 的含量是什么 1H,1H,9H- perfluorononyl 烯酸盐是一种1H,1H,9H- perfluorononyl 烯酸盐.2-chloro-2,3,3,3-tetrafluoropropanoic 酸的使用情况和多醇基物质是多和多的.甲基七多烯基甲基七多烯基从口服中获得的亚慢性毒性.

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