多功能向上转换纳米粒子转换光声成像:一篇评论
Yuqian Zhang1, Zerui Li2, Ziqing Du3
1Nepean Hospital, Kingswood, NSW 2747, Australia.
Nanomaterials (Basel, Switzerland)
|July 25, 2025
概括
上转化纳米粒子 (UCNPs) 为光声成像 (PAI) 提供独特的光学性能. 这篇评论强调了它们作为先进生物医学诊断和治疗的对比剂的潜力.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 纳米技术纳米技术
- 光学是什么?光学是什么?光学是什么?
背景情况:
- 光声成像 (PAI) 结合了光学分辨率与超声波的组织透.
- 多种不同的对比剂对于PAI的发展至关重要.
- 上转化纳米粒子 (UCNPs) 具有独特的光学特性和可调节的近红外吸收.
研究的目的:
- 审查UCNP在光声成像中的重要性.
- 讨论UCNP的结构特征,优势和局限性.
- 在PAI文献中提供UCNP应用的最新记录.
主要方法:
- 在光声成像中对UCNP的文献综述.
- 对UCNP结构性质和光学特征的分析.
- 评估UCNP作为PAI中的对比剂的性能.
主要成果:
- 由于可调节的NIR吸收和独特的光学特征,UCNP显示出作为对比剂的希望.
- 在各种PAI应用中,UCNP已经证明了其潜力.
- 目前的文献展示了PAI的各种UCNP开发.
结论:
- UCNP是PAI的重要新兴对比剂.
- 需要进一步的研究来应对临床翻译的挑战.
- UCNPs对临床前和临床诊断应用具有前景.
相关概念视频
Imaging Biological Samples with Optical Microscopy
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Phase Contrast and Differential Interference Contrast Microscopy
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
Super-resolution Fluorescence Microscopy
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.


