相关实验视频

Updated: Sep 13, 2025

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Published on: September 13, 2024

奥米克朗影响仓鼠的嗅觉

Virginie Guérin¹, Mantasha Khan^2,3, Clara Bourgon²

¹UMR 1161 Virologie, INRAE-ENVA-ANSES, École Nationale Vétérinaire d'Alfort, Paris, France.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|July 25, 2025

概括

奥米克朗BA.1感染会导致子的低嗅 (减少嗅觉),影响鼻腔. 尽管最初的嗅觉上皮的影响比早期的变体不那么严重,但Omicron导致类似的嗅觉丧失和持续的炎症.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

嗅觉障碍,包括厌氧症,在早期的SARS-CoV-2变种中很常见.
奥米克朗 (BA.1) 变种的出现导致厌氧症的流行率下降,减少了对其鼻腔病理生理学的研究兴趣.

研究的目的:

通过使用仓鼠模型,研究鼻腔中Omicron BA.1感染的病理生理学及其对嗅觉功能的影响.
为了比较Omicron BA.1与早期SARS-CoV-2变种 (D614G) 对嗅觉和呼吸道上皮质的影响.

主要方法:

感染SARS-CoV-2 Omicron BA.1 和 D614G 变种的仓鼠模型.
嗅觉功能的评估 (低血症).
鼻腔组织的组织病理学分析,包括嗅觉和呼吸道上皮质,感染后2,4,8天 (dpi).
评估炎症标志物,上皮损伤和病毒存在.

主要成果:

奥米克朗BA.1感染导致低血,从2dpi开始,呼吸道上皮质严重感染,并显示出炎症和损伤.
虽然嗅觉上皮最初没有受到影响,但Omicron BA.1感染了4dpi,导致免疫细胞入侵和脱皮,类似于D614G.
即使在病毒清除后,也在8dpi时观察到嗅觉轮的持续炎症,嗅觉功能障碍与以后的D614G感染相似.

结论:

奥米克朗BA.1感染鼻上皮质,包括嗅觉上皮质,尽管比早期的SARS-CoV-2变种更晚,而且程度更小.
在患有Omicron感染的人群中观察到的嗅觉敏感性下降可能与上皮损伤和嗅觉裂中的细胞碎片有关.
这项研究强调了嗅觉功能障碍的潜力,即使在变体显示低解流行率的情况下也是如此.

关键词:

嗅觉嗅觉是一种嗅觉.嗅觉行为是一种嗅觉行为.呼吸道病毒的病毒.

更多相关视频

Testing for Odor Discrimination and Habituation in Mice

Testing for Odor Discrimination and Habituation in Mice

Published on: May 5, 2015

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

相关概念视频

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...