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肉类消费与发生急性胰腺炎之间的关联:一项前性队列研究
Tianyi Che1, Qijia Gong2, Jiawei Geng3
1Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Ruijin Second Road, Shanghai 200025, China. zch12228@rih.com.cn.
较高的加工肉类摄入量增加了急性胰腺炎的风险,而鱼类消费则降低了风险. 用鱼代替加工肉可以降低患急性胰腺炎 (AP) 的风险.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,肉类消费与急性胰腺炎 (AP) 病因之间存在联系,但缺乏明确的结论.
- 不同类型的肉类与事件AP风险之间的具体关联仍然不清楚.
研究的目的:
- 调查加工肉,未加工红肉,家禽和鱼类的消费与发生急性胰腺炎的风险之间的关系.
- 量化鱼类取代加工肉对AP风险的影响.
主要方法:
- 一项大型队列研究涉及489,708名来自英国生物银行 (2006-2010) 的参与者.
- 使用食物频率问卷和验证的24小时回忆来准确测量肉类消费量的饮食摄入量.
- 考克斯的比例危险模型被用来分析肉类摄入量和事件AP之间的关联,平均随访时间为13.2年.
主要成果:
- 较高的加工肉类消费与发生事件AP的风险增加显著相关 (HR:1.29每25g/天).
- 相反,较高的鱼类消费与AP风险降低有关 (HR:0.78每25g/天).
- 用鱼代替加工的肉类证明了剂量依赖的AP风险降低,从6%到16%不等.
结论:
- 经常食用加工肉类与发生急性胰腺炎的风险更高有关.
- 增加鱼类摄入量与发生急性胰腺炎的风险较低有关.
- 饮食修改,特别是用鱼代替加工肉类,可能是减轻AP风险的可行策略.
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