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在癌症幸存者中,放射后的末期膀简单囊切除术与隐性恶性瘤无关
Logan W Grimaud1, Thomas E Schroeder2, Mariela Martinez1
1Department of Urology, Duke University School of Medicine, 2301 Erwin Rd, Durham, NC, 27710, USA.
World journal of urology
|July 25, 2025
概括
在盆腔辐射后进行简单的囊切除术对于癌症幸存者来说是安全的. 这项研究在接受手术的患者中没有发现二次膀癌,这表明了这一点.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 癌症的盆腔放射治疗可能导致严重的膀并发症,需要囊切除术.
- 简单的囊切除术对于这些患者来说,与激进的囊切除术相比,是一种不那么侵入性的手术选择.
- 一个关键的担忧是辐射后样本中未被检测到的二次膀恶性瘤的可能性.
研究的目的:
- 为了评估二次膀恶性瘤的发病率,从有骨盆辐射病史的患者中简单的囊切除样本.
- 在癌症幸存者中评估简单囊切除术的瘤安全性,这些癌症幸存者先前接受了盆腔辐射治疗.
主要方法:
- 对2010年至2023年期间进行的良性囊切除术的回顾性审查.
- 纳入标准:骨盆放射治疗史;排除标准:先前的泌尿器癌,恶性瘤的囊切除术,非癌症的迹象,没有辐射史.
- 囊切除样本的外科病理学被分析为残留或二次恶性瘤.
主要成果:
- 111名先前接受盆腔辐射的患者符合纳入标准;前列腺癌是最常见的原发性恶性瘤.
- 没有患者 (0%) 在辐射后的简单囊切除样本中显示出尿路细胞恶性瘤的证据.
- 在没有进行前列腺切除术的前列腺癌患者中观察到低残留前列腺癌率 (4.8%).
结论:
- 在这组经历了盆腔辐射后简单囊切除术的患者中,没有检测到二次膀恶性瘤.
- 简单的囊切除似乎是一个安全和合理的手术选择,癌症幸存者与辐射诱导的膀问题,当瘤控制不是主要目标.
- 在仅用放射治疗的患者中,残留前列腺恶性瘤的发病率较低.
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