血造干细胞移植后的幽默免疫:通过B细胞受体谱分析进行评估

相关实验视频

Updated: Sep 13, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.4K

Sakuya Matsumoto1, Yohei Funakoshi2, Kimikazu Yakushijin1

  • 1Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Hospital and Graduate School of Medicine, Kobe, Japan.

International journal of hematology
|July 25, 2025
PubMed
概括

在血液造血干细胞移植 (HSCT) 后,首次SARS-CoV-2疫苗接种会诱导初级免疫反应,即使之前暴露于抗原. 这一发现对于理解移植后免疫力和疫苗接种策略至关重要.

关键词:
乙细胞受体谱B细胞受体谱冠状病毒抗体数据库造血干细胞移植 造血干细胞移植对抗原特异性抗体序列的量化.这是mRNA疫苗.

更多相关视频

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.4K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.5K

相关概念视频

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
802
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
5.9K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
72.9K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
4.2K