术后抗生素策略在急性复杂尾炎:一个系统的审查
Hussayn Shinwari1, Béatrice Marianne Ewalds-Kvist2,3, Michael El Boghdady4
1St George's University Hospitals NHS Foundation Trust, London, UK.
术后较短的抗生素疗程 (2-6天) 对于复杂的尾炎,与较长的疗程一样有效. 早期过渡到口服抗生素也可以减少住院时间和费用,而不会增加并发症.
科学领域:
- 手术传染病手术传染病
- 抗生素管理局 抗生素管理局
- 胃肠道手术 胃肠道手术
背景情况:
- 急性尾炎是经常出现的手术紧急情况.
- 复杂的尾炎增加了感染和发病风险.
- 最佳的术后抗生素策略尚不清楚.
研究的目的:
- 审查目前关于术后抗生素管理复杂尾炎的证据.
- 为指导尾炎管理的最佳治疗策略.
- 为了向临床实践提供有关尾切除术后抗生素使用的信息.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在PubMed和Cochrane数据库中搜索相关研究.
- 包括RCT,队列和观察性研究;评估偏差风险和证据确定性.
主要成果:
- 包括11项研究,共8361名参与者.
- 较短的静脉注射抗生素疗程 (2-6天) 与较长的疗程没有劣势.
- 口服抗生素在选定的患者中是有效的;较短的疗程减少了住院时间和费用.
结论:
- 较短的静脉注射抗生素疗程和早期的口服过渡对于复杂的尾炎是有效的.
- 基于患者的风险因素和手术内发现的个性化治疗至关重要.
- 这些发现支持抗生素管理,并表明需要对高风险群体进行进一步研究.
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