相关实验视频

Updated: Sep 13, 2025

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

内微生物与肝细胞癌中DNA甲基化基因表达相关

Wei Chen^1,2,3,4, Xiang Zhang^1,2,3,4, Minhui Chi^1,2,3,4

¹Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian Province, China.

Digestive diseases and sciences

|July 25, 2025

概括

内瘤细菌通过与DNA甲基化基因相互作用,影响肝细胞癌 (HCC). 特定的细菌系表现出改变的丰富性和与关键基因的相关性,这表明HCC的新治疗点.

科学领域:

在瘤学瘤学.
微生物学微生物学
遗传学是一个遗传学.

背景情况:

内微生物群因其在癌症发展中的作用而越来越被认可.
有证据表明,肠道细菌与肝细胞癌 (HCC) 中的DNA甲基化通路之间存在联系.

研究的目的:

研究HCC组织中特定细菌属和DNA甲基化相关基因之间的相互作用.
为了确定内微生物群和HCC进展之间的潜在机械联系.

主要方法:

来自72名HCC患者的瘤和相邻正常组织的分析.
16S rRNA测序用于细菌组成的表征.
对不同细菌属和DNA甲基化途径基因表达的定量评估.

主要成果:

六个细菌系 (Propionibacterium,Mycoplasma,Variovorax,OPB41,未分类_Bifidobacteriaceae,Rikenellaceae) 在HCC组织中表现出不同的丰度.
确定了特定细菌 (Propionibacterium,Mycoplasma,Pseudomonas) 和关键的DNA甲基化基因 (SPOCD1,EOMES,BMI1,EZH2) 之间的负相关性.
伪菌的丰富性与Propionibacterium和Mycoplasma有负相关性.

结论:

这项研究揭示了内细菌与通过DNA甲基化调节的HCC进展之间的潜在机械联系.
这些微生物群-基因相互作用为未来的HCC治疗策略提供了新的目标.

关键词:

它们是DNA DNA DNA DNA.弗洛拉·弗洛拉 (Flora Flora) 是一个植物.肝细胞癌是肝细胞癌.内微生物内微生物甲基化甲基化甲基化

更多相关视频

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

相关概念视频

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...