综合征的胃肠道表现 (NOD2相关的自身炎症性疾病)
John A Damianos1, Avinash K Nehra2, Joseph A Murray3
1Mayo Clinic Division of Gastroenterology and Hepatology, Rochester, MN, USA. damianos.john@mayo.edu.
综合征 (YAOS) 的胃肠道症状是普遍的和严重的,通常以膨胀和便秘的形式呈现. 这些症状可能源于炎症和非炎症原因,可能与不协同的排便有关.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 综合征 (YAOS) 是一种NOD2相关的自身炎症性疾病.
- 在患有特定NOD2变异的患者中,表现为发烧,皮肤炎,多关节炎,四肢胀和胃肠道症状.
- 胃肠道表现是一种标志性特征,但其特定的症状和机制仍然不太清楚.
研究的目的:
- 为了全面评估患有综合征的患者的胃肠道症状.
- 调查导致这些胃肠道症状的潜在机制.
主要方法:
- 从一个机构数据库中识别了24名YAOS患者.
- 使用胃肠道症状评分表问卷评估呈现胃肠道症状.
- 系统地分析了与胃肠道相关的血液工作,便研究,成像,内镜和运动性测试.
主要成果:
- 100%的患者报告了胃肠道症状,而胀气是最突出的.
- 大多数标准的胃肠道检查,包括活检和成像,都正常;过度的便负担是常见的.
- 在所有被测试患者中,用气球驱逐测试进行直肠测量是异常的,这表明不协同的排便;少数人患有诸如乳病或微观结肠炎等相关疾病.
结论:
- 在YAOS中,胃肠道症状是普遍的和严重的,来自炎症和非炎症途径.
- 在YAOS患者中,胀气和便秘可能归因于不协同的排便.
- 需要进一步研究YAOS的复杂肠胃表现.
更多相关视频
03:25Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment
Published on: December 27, 2024
08:42Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
相关概念视频
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Other Disorders of Digestive System
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Gastrointestinal Motility Disorders
