多发性硬化症患者的疲劳及其促进因素:一个横截面研究
Ida Mohammadi1, Saeed Vaheb2, Shahryar Rajai Firouzabadi1
1School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Neurological research
|July 25, 2025
概括
疲劳在多发性硬化症 (MS) 中普遍存在,并与抑郁症,下肢功能较差和身体活动减少有关. 了解这些因素可以帮助MS患者管理疲劳.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 精神病学是一个精神病学.
背景情况:
- 疲劳是多发性硬化症 (PwMS) 患者的常见和衰弱症状.
- 在PwMS中导致疲劳的因素尚未完全理解.
- 这项研究旨在调查疲劳严重程度与PwMS中的各种因素之间的关系.
研究的目的:
- 检查多发性硬化症患者的疲劳严重程度与体力活动,四肢功能,情绪和人口统计数据之间的关联.
- 在统一的框架内确定导致PwMS疲劳的关键因素.
主要方法:
- 一项涉及141名患有多发性硬化症 (PwMS) 的伊朗伊斯法罕人的横截面研究.
- 收集的数据包括疲劳严重程度 (疲劳严重程度尺度),人口统计,认知处理速度 (符号数字模式测试),身体活动 (IPAQ),上肢和下肢功能 (9洞脚测试,定时25英尺步行),抑郁和焦虑 (贝克库存).
- 使用逐步线性和逻辑回归模型分析疲劳严重程度和其他因素之间的关联.
主要成果:
- 在参与者中,疲劳的患病率为61.7%.
- 更高的疲劳严重程度与更大的抑郁症,较差的下肢功能,渐进式多发性硬化和较低的体力活动有关.
- 结婚,下肢功能恶化和更高的抑郁症得分与临床显著疲劳的几率增加有关.
结论:
- 疲劳在PwMS中很常见,并且独立地与抑郁症,下肢功能减弱,进展性MS,体力活动降低和婚姻状况有关.
- 这些发现突出了导致PwMS患者疲劳的关键身体和心理因素.
- 建议进行纵向研究以确定因果关系.
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