相关实验视频

Updated: May 5, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

Published on: October 18, 2013

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对超过1万种先进的固体瘤进行了全面的基因组分析

Jean-Paul De La O1, Jess R Hoag1, Angela K Deem1

  • 1Exact Sciences Corporation, Madison, WI 53719, USA.

Oncotarget
|July 25, 2025
PubMed
概括

超过92%的固体瘤样本存在治疗可行的基因组改变. 在OncoExTra测定确定临床相关的突变和融合,帮助治疗决策的晚期癌症.

关键词:
进行全面的基因组分析.基因融合 基因融合检测的检测极限.匹配治疗疗法 匹配治疗疗法固体瘤是一种固体瘤.

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相关概念视频

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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