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自动化胰岛素输送和碳水化合物发布的长期模式:24个月的随访
Estelle Godard1, Alfred Penfornis1,2, Coralie Amadou1,2
1Department of Endocrinology and Diabetes, Sud-Francilien Hospital, Corbeil-Essonnes, France.
Diabetes technology & therapeutics
|July 25, 2025
概括
自动化胰岛素输送系统在治疗1型糖尿病方面表现出持续的有效性. 尽管碳水化合物报告数量下降,但自动的百分比增加,这表明了适应性用户行为和一致的血糖控制.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 生物医学工程 生物医学工程
背景情况:
- 自动注射胰岛素 (AID) 系统,如控制IQ,旨在改善1型糖尿病的血糖控制.
- 用户输入的长期一致性,例如碳水化合物计数和餐点预告,对于AID有效性至关重要.
- 了解用户行为模式及其对AID系统内的代谢控制的影响是必不可少的.
研究的目的:
- 评估24个月内控制IQ用户的碳水化合物计数和餐点预告的长期一致性.
- 分析自百分比和每日碳水化合物公告 (DCA) 的趋势及其与代谢控制 (时间范围 - TIR) 的关联.
- 为了研究自百分比与包括年龄,性别,DCA和TIR在内的因素之间的关系.
主要方法:
- 单中心回顾性队列研究分析了从2021年10月到2024年10月的数据.
- 包括来自控制IQ用户的2751人四分之一 (57%是女性,平均年龄37岁).
- 使用混合效应线性模型来评估自动玻璃百分比,DCA和TIR的趋势和关联.
主要成果:
- 平均自囊百分比为61%,每季度显著增加0.4% (P < 0.001).
- 在研究期间,每日碳水化合物公告 (DCA) 从132g/day下降到100g/day.
- 时间在范围 (TIR) 略有下降,从61%降至58%;自动玻尿酸百分比与年龄,TIR和DCA相反相关.
结论:
- 自动注射胰岛素的持续有效性得到证实,随着自动注射的百分比增加,尽管用户碳水化合物报告下降,但该系统的适应性得到了提醒.
- 随着时间的推移,观察到的自动骨头百分比和DCA之间的反向关联得到了加强,突出显示了对AID的适应性用户行为.
- 在TIR中适度的变化表明,AID系统可以有效地保持代谢控制,即使减少了用户对碳水化合物摄入量的明确输入.
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